自发性高血压大鼠血压波动、昼夜模式及靶器官损伤

VARIABILITY AND CIRCADIAN PROFILE OF BLOOD PRESSURE AND TARGET ORGAN DAMAGE IN SPONTANEOUSLY HYPERTENSIVE RATS

分析造成高血压靶器官损伤的多元因素。方法 :以自发性高血压大鼠 (SHR)为动物模型 ,进行 2 4h动态血压监测 ,分析血压波动性、血压昼夜模式与靶器官损伤的关系。结果 :SHR不同的时间段的收缩压波动性、舒张压波动性均与靶器官损伤显著正相关 ,且相关程度较血压水平与靶器官损伤的相关更为密切 ;非勺型血压SHR的靶器官损伤较勺型血压SHR明显严重。结论 :血压波动性。

Objective:To analysis various contributing factors to hypertension related target organ damage (TOD).Methods:Intra-arterial blood pressure (BP) was continuously recorded for 24h in freely moving spontaneous hypertensive rats (SHR) by a micro-computer system. On-line and off-line computer analysis of the BP curve allowed calculation of systolic(SBP), diastolic (DBP) blood pressure and blood pressure variability.The rats could be divided into two groups:'dippers'and 'non-dippers'. The relationship between variability and circadian profile of blood pressure and TOD was studied in SHR.Results:SBP,DBP and their variabilities were all significantly correlated to TOD, while the variabilities of SBP and DBP were correlated to TOD more significantly than average value of SBP or DBP.The TOD induced by hypertension was more severe in 'non-dippers'than in 'dippers'.Conclusions:Variability and circadian profile of blood pressure are important factors contribute to TOD.