血清总胆汁酸测定在慢性肝炎与肝炎后肝硬化的临床意义

The clinical significance of determination for the serum total bile acid in chronic hepatitis and post-hepatitic cirrhosis

目的 探讨慢性肝炎、肝炎后肝硬化患者血清总胆汁酸 (TBA)的临床意义。方法 经肝穿活检病理证实为慢性肝炎、肝炎后肝硬化者 ,测定其TBA ,并与ALT、Tbil进行对比分析。结果 慢性肝炎、肝炎后肝硬化TBA与正常组比较有显著性差异。结论 慢性肝炎、肝炎后肝硬化时TBA检测与ALT、Tbil同样具有高度的敏感性 ,并可判断病情的预后。

Objective To understand the clinical significance of determining the serum total bile acid (TBA) in chronic hepatitis and post-hepatitic cirrhosis. Methods All patients were biopsied to prove chronic hepatitis (82 cases) and post-hepatitic cirrhosis (24 cases). TBA was tested and contrasted to ALT and total bilirubin (Tbil). Results There was a significant difference between the groups of chronic hepatitis, post-hepatitic cirrhosis and the normal control group. Conclusions The determination of TBA has the similar sensitivity as ALT and Tbil in chronic hepatitis and post-hepatitic cirrhosis, and it may predict the prognosis.