哌仑西平治疗十二指肠球部溃疡远期疗效及复发的观察

Observation on the long-term therapeutic efficacy of Pirenzepine on treatment of duodenal ulcer

目的 观察哌仑西平治疗十二指肠球部溃疡的远期疗效及复发情况。方法 63例经胃镜明确诊断十二指肠球部溃疡的患者随机分为A、B、C 3组 ,分别以哌仑西平、雷尼替丁及哌仑西平加雷尼替丁进行为期 4周的短期治疗 ,然后对各组经胃镜检查确定为治愈的患者定期随访一年 ,最后由胃镜检查了解溃疡复发情况。结果 A组 (哌仑西平 )和C组 (哌仑西平加雷尼替丁 )复发率分别为 3 6 4%和 3 3 3 % ,明显低于B组 (雷尼替丁的 81 8% ) ,统计学上有显著差异 (P <0 0 5 )。结论 用哌仑西平治疗十二指肠球部溃疡能降低停药后的溃疡复发率。

Aim To observe the long term therapeutic efficacy of pirenzepine on treatment of duodenal ulcer and the recurrence. Methods Sixty three patients with duodenal ulcer confirmed by endoscope were randomly divided into three groups: Group A was treated with pirenzepine (50 mg twice per day orally for 4 weeks); Group B with ranitidine (150 mg twice per day orally for 4 weeks); and Group C with a combination of pirenzepine (the same dosage as Group A) and ranitidine (the same dosage as Group B). After 4 weeks of medication, all patients were examined again by endoscope by the same endoscopist. All patients with healed ulcer confirmed by endoscopy from the three groups were followed up for one year. On the end of the follow up, all the patients with healed ulcer took a third endoscopy to find out if any recurrence of ulcer had taken place.Results Group A and Group C had a recurrence rate of 36.4% and 33.3% respectively, which were much lower than that in Group B (81.8%). The difference was statistically significant ( P <0.05). Conclusion Duodenal ulcer patients cured with pirenzepine have a lower recurrence rate than those with ranitidine.