全国医院感染监控网医院感染病原菌分布及耐药性分析

Distribution and Antibacterial Resistance of Nosocomial Infection Pathogens from National Nosocomial Infection Surveillance System

目的 了解医院感染病原菌的排序及细菌的耐药情况。方法 对全国医院感染监控网 79所医院医院感染病原菌来源及细菌耐药性进行统计分析。结果 在 4 0 6 88例医院感染患者中共分离出病原菌 12 2 96株 ,分离阳性率为 2 6 .6 8% ,病原菌仍以革兰阴性需氧杆菌为主 ,占 4 7.98% ,革兰阴性杆菌除嗜麦芽窄食单胞菌外 ,对亚胺培南的敏感率均在 80 %以上 ;与未加酶抑制剂抗菌药相比 ,大多数医院感染革兰阴性菌对加酶抑制剂抗菌药耐药率均有不同程度的下降 ,尤其以头孢哌酮与头孢哌酮 /舒巴坦明显 ,两者比较差异有显著性 (P<0 .0 5 ) ;耐甲氧西林葡萄球菌检出率达 75 .36 %。结论 为控制细菌的耐药性 。

OBJECTIVE To investigate the distribution and drug resistance of nosocomial infection pathogens. METHODS Statistical methods were used to analyse the data of pathogen′s origin and antibacterial resistance from 79 hospitals of NISS. RESULTS We are isolated 12 296 strains from 46 088 nosocomial infection cases (26.68%), from which the Gram negative bacilli were predominate (47.98%). Except Stenotrophomonas maltophilia, the rate of imipenem susceptible Gram negative bacilli was over 80%. The resistance rates of antibiotics combinating with beta lactamase inhibitors were lower than those with no combinating with beta lactamase ones. Especially in cefoperazone vs cefoperazone/sulbactuam, the difference between them were significant. The rate of meticillin resistant Staphylococcus was 75.36%. CONCLUSIONS For control of the antibacterial resistance of pathogens, appropriate use of antibiotics must be strengthened.