重症急性胰腺炎合并深部真菌感染(附40例报告)

Fungal infection in severe acute pancreatitis (a report of 40 cases)

目的 探讨重症急性胰腺炎 (SAP)合并深部真菌感染的临床特点及相关因素。方法 回顾分析对比 1994年 1月～ 2 0 0 1年 12月SAP合并真菌感染 (真菌组 )和单纯细菌感染 (细菌组 )病例的临床资料。结果 真菌组 40例 ,细菌组 84例 ;两组的年龄、性别、病因、APACHEII评分差异均无显著性 ,真菌组住院时间明显比细菌组长 ( P =0 .0 44) ;糖尿病、SAPII级、多次手术、肠和 /或胆瘘与真菌感染相关 ;真菌组的死亡率明显高于细菌组 (P =0 .0 2 )。结论 糖尿病、SAPII级、多次手术、肠和 /或胆瘘是SAP发生真菌感染的危险因子 ;真菌组的死亡率明显增高。胰外器官真菌感染多见于消化道、呼吸道、泌尿系。不明原因的意识改变、大出血应高度怀疑真菌感染。

Objective To study the clinical characteristic and correlation factors of fungal infection in severe acute pancreatitis(SAP). Methods Clinical data of SAP patients with fungal infection (fungus infection group-F1 group) and with bacterial infection (bacteria infection group, B1 group) in January,1994-December,2001 were retrospective analysed and compared. Results There were 40 cases in F1 group, 84 cases in B1 group. There were no significant difference in age, sexual, causes, APACHE II score between the two groups, Hospitalization in F1 was significantly longer than that in B1 group (57.7d∶42.7d, P= 0.044 ).Diabetes-mellitus, SAP grade II, multi-operation, intestinal and/or bile duct fistulas were related to fungal infection in SAP; mortality in F1 group was significantly higher than that in B1 group (P= 0.02 ). Conclusions Diabetes-mellitus, SAP grade II, multi-operation, intestine and/or bile duct fistulas are the risk factors of patients with severe acute pancreatitis developing fungal infection; fungus infection can increase the mortalily of SAP patients.Extra-pancreas fungal infection is commonly seen in digestive tract, respiratory tract and urinary system. unknown consciousness change and massive bleeding may indicate that the patient is complicated with fungal infection.