溃疡性结肠炎患者血清IL-18的变化及意义

Change and sense of serum IL-18 level of ulcerative colitis patients

目的 :探讨 IL -18在溃疡性结肠炎 ( U C)发病中的作用。方法 :采用固相酶联免疫分析( ELISA)法检测 36例 U C患者血清 IL-18含量。结果 :U C活动期患者血清 IL-18含量较健康对照组明显升高 ( P<0 .0 1) ,并与病情的轻重和病变的范围有关 ( P<0 .0 5 ) ,而 U C缓解期患者与健康对照组间无显著性差异 ( P>0 .0 5 )。结论 :IL-18可能参与 U C的发病 ,血清 IL-18可作为 U C病情判断的参考指标。

Objective: It is to study the role of IL-18 in the pathogenesis of ulcerative colitis (UC). Methods: An enzyme-linked immunosorbent assay (ELISA) was utilized to detect the serum IL-18 level of 36 UC patients. Results: The serum IL-18 level in acute period of UC patients was significantly higher than that in control group ( P <0.01). The serum IL-18 level was closely related with the degree of UC (P <0.05). There was no significant difference between remisson period of UC and control ( P >0.05). Conclusion: IL-18 might play an important role in the pathogenesis of UC. The measurement of IL-18 is helpful to estimate the disease activity of UC and it may be considered as laboratory criteria for UC.