急性心肌梗塞不同时期微循环血液流变的动态变化

Dynamic Changes of Microcirculation and Blood Rheology in Different Periods after Acute Myocardial Infarction

目的 :研究冠心病患者急性心肌梗塞 (AMI)后不同时期甲襞微循环、血液流变性动态变化 ,为AMI患者的康复期拟定二级预防方案提供依据。方法 :采用XDM 30 0B型显微镜及SA B型血液流变检测仪分别测定AMI后不同时期及相应对照组的甲襞微循环、血液流变学。结果 :(1)AMI后 1个月、3个月甚至半年管攀内血流仍缓慢 ,呈粒流、粒缓流 ,出现不同程度细胞聚集及管攀周围轻重不等渗出。AMI后 1个月甲襞微循环异常显著 ,积分值升高。 (2 )AMI后 1个月 ,除红细胞压积外均明显高于对照组 ,同时也高于AMI后 3,6 ,12 ,2 4个月及 36个月。纤维蛋白及红细胞电泳时间在AMI后 1年仍高于正常值。结论

Objective:To study the dynamic changes of microcirculation and blood rheology in coronary heart disease patients in defferent periods after acute myocardial infarction (AMI)and to provide a basis of secondary prevention plan for convalescents. Methods:Measuring the microcirculation of nail fold and blood rheology of both patients in different periods after AMI and healthy people. Results:(1)Blood stream in capillary loops flowed slowly as granular or slow granular stream and cell aggregation and exudation existed to different degrees in 3-6 months after AMI. Microcirculation of nail fold was very distinct and integral value enhanced after one month of AMI .(2) In one month after AMI, all the tested values of patients except hematocrit were higher than those of control group and were also higher than those of patients in 3,6,12,24 and 36 months after AMI .After one year of AMI ,fibrinogen and red blood cell electropheresis time of patients were still higher than those of control group.Conclusion:Microcirculation and body blood rheology after AMI have a certain dynamic alteration regularity.