Alzheimer′s病和血管性痴呆特征的比较研究

Comparison of the Features Between Alzheimer′s Disease and Vascular Dementia

目的 :旨在通过对AD和VaD临床特征、流行特征和认知功能三方面的对比分析 ,为两者的病因学研究、鉴别诊断、治疗和预防提供依据。方法 :选取 1997～ 1998年上海地区流行病学调查中的确诊AD和VaD病人。结果 :在四项心理测验FOM ,RVR ,DS和BD项中 ,只有BD项表现为AD高于VaD(P <0 0 5 )。AD女性患病率是男性的 2倍 ,VaD患病率男性高于女性 ;AD患病率自 75～ 90岁以上呈倍数上升 ,而VaD 90岁以后的患病率反而下降。AD有文化程度的差别 ,VaD的患病率和文化程度的关系不明显。结论 :AD和VaD在临床特征。

Aim:To put forward a support for the etiology study,diagnosis,treatment and prevention on Alzheiemer′s disease(AD) and vascular dementia(VaD)by comparing the clinical features,epidemic characteristics and cognition between AD and VaD.Methods:Participants were the cases who were diagnosed correctly in the investigation from 1997 to 1998 in Shanghai area.Results:In the neuropsychology tests of FOM,RVR and DS,there is no significance between AD and VaD.But there is significance in the test of BD that the score of AD was higher than VaD. Compared with VaD,the female prevalence of AD was twice as male,while the prevalence of AD was higher than VaD,the age specific prevalence of AD was increased double by aging till above 90 years old,while the age specific prevalence of VaD was decreased after 90 years old.There was difference of AD prevalence on education,while the standard prevalence of VaD had no sigificance.Conclusion:There is distinction on clinical and epidemic features and cognition between Alzheimer's disease and vascular dementia.