肺硬化性血管瘤病理形态及免疫表型

Pulmonary sclerosing hemangioma:a pathomorphological and immunophenotypic study

目的 :分析 11例肺硬化性血管瘤的组织学及免疫表型特点 ,探讨该肿瘤的组织起源。方法 :用免疫组化LSAB法检测14种抗原在石蜡切片中的表达。结果 :衬覆细胞 :阳性表达CKL11例、EMA 11例、CEA 4例、Vim 8例、NSE 5例、S 10 0蛋白3例 ,而Syn、CgA、p5 3及CD34分别有 2例、2例、1例、2例可见少数阳性细胞。实性细胞 :阳性表达CKL5例、EMA 11例、Vim 10例、NSE 6例、S 10 0蛋白 3例 ,而Syn、CEA、p5 3、CD34分别有 2例、5例、1例、2例有少数阳性细胞 ,实性细胞不表达CgA。两类细胞均不表达Calr、FⅧRAg、Mac387(4/ 4 )、CD6 8(4/ 4 )。结论 :肺硬化性血管瘤是上皮源性肿瘤 ,衬覆细胞和实性细胞均为肿瘤成分 ,因此用Chan提出的“良性硬化性肺细胞瘤”

Purpose To investigate the pathomorphological and immunophenotypic features of pulmonary sclerosing hemangioma (SH), and to discuss the histogenesis of this tumor. Methods Immunohistologic stains were applied to paraffin sections, and 14 kinds of antibodies were observed. Results The lining cells of SH were positive for CK L (11 cases), EMA (11 cases), CEA (4 casess),Vim (8 cases), NSE(5 cases) and S 100 (3 cases), they had a few positive cells for Syn (2 cases), CgA (2 cases), p53 (1 cases),CD34 (2 cases). The stromal cells of SH were positive for CK L (5 cases), EMA (11 cases),Vim (10 cases),NSE (6 cases) and S 100 (3 cases), they had a few positive cells for Syn (2 cases),CEA (5 cases),p53 (1 case),CD34 (2 cases), while they were negative for CgA. These two kinds of cells were both negative for Calr,FⅧRAg,Mac387(4/4),CD68(4/4). Conclusions Pulmonary sclerosing hemangioma is an epithelial tumor; moreover both the lining cells and the stromal cells are neoplastic. The term 'benign sclerosing pneumocytoma of lung' suggested by Chan would be more appropriate for this tumor.