原发性心脏恶性肿瘤9例临床病理分析

Primary cardiac malignant tumors:a clinical pathologic analysis of 9 cases

目的 :分析原发性心脏恶性肿瘤 (PCMT)的发病学特点、病理组织类型及形态学基础。方法 :应用HE染色 ,组化及免疫组化标记对 9例PCMT进行了形态学观察 ,并对其临床资料作了分析。结果 :根据形态学发现和免疫组化结果 ,9例PCMT可分为心脏恶性间皮瘤 (3例 )、血管肉瘤 (2例 )、B细胞淋巴瘤 (2例 )、心包胸腺瘤 (1例 )及交界性上皮样血管内皮瘤 (1例 )。结论 :PCMT很少见 ,多见于中年男性 ,好发于心房 ,多数恶性肿瘤预后差 ,肿瘤类型多 ,形态结构复杂 ,免疫组化标记对确定肿瘤起源很有帮助 ,早期发现、准确诊断与局部肿瘤全切除 。

Purpose To study pathogenic characteristics, histologic types and morphotogic bases for primary cardiac malignant tumors (PCMT). Methods Pathomorphology of 9 cases of PCMT was observed with HE staining?histochemistry and immunohistochemistry, and their clinical data were analysed. Results According to morphologic finding and immunohistochemical staining, 9 cases of PCMT were classified into the cardiac malignant mesothelioma (3 cases), hemangioendotheliosarcoma (2 cases),B cell lymphoma (2 cases),prericardiac malignant thymoma (1 case) and borderline epithelioid hemangioendothelioma(1 case). Conclusions PCMT is extremely rare. Clinically, most patients are middle males. Most of the tumors arise in the atrium and the prognosis for most of the PCMT is evidently very poor. There are many types in PCMT, and their morphologic structures are complex. It is very helpful to use immunohistochemical staining to find out the histogenesis of PCMT, and it is very important for treatment and prognostic analysis of PCMT in early and accurate diagnosis and local complete excision.