1[1]Steck PA, Pershouse MA, Jasser SA et al. Identification of candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancer. Nat Genet, 1997;15:356～62
2[2]Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science, 1997;275:1943～7
3[3]Myers MP, Stolarov P, Eng C. PTEN, the tumor suppressor form human 10q23, is a dual specificity phosphatase. Proc Natl Acad Sci USA, 1997;94:9052～7
4[4]Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate. J Biol Chem, 1998;273:13375～8
5[5]Piao Z, Park C, Park JH et al. Allelotype analysis of hepatocellular carcinomas. Int J Cancer, 1998;75:29～33
6[6]Furnari FB, Lin H, Huang HS et al. Growth suppression of glioma cells by PTEN requires a functional phosphatase canalytic domain. Proc Natl Acad Sci USA, 1997;94:12479～84
7[7]Myers MP, Pass I, Barry IH et al. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci USA, 1998;95:13513～8
8[8]Li J, Simpson L, Takaheshi M et al. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res, 1998;58:5667～72
5Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer[J]. Science ,1997,275 ( 5308): 1943-1947.
6Fleming I D, Cooper J S, Henson D E, et al. Eds: American Joint Committee on Cancer[M]. 5th ed. Manual for Staging of Cancer, Lippincott Philadelphia, 1997. 220- 224.
7Gleason D F. The Veterans Administration Cooperative Urological Research Group: Histological grading and clinical staging of prostatic carcinoma. In Tannenbaum M, ed: Urologic pathology. The prostate[M]. Philadelphia, 1977. 171- 198.
8Gleason D F. Histologic grading of prostate cancer: a perspective[J]. Hum Pathol,1992,23(3): 273-279.
9Ramaswamy S, Nakamura N, Vazquez F, et al. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway [J]. Proc Natl Acad Sci USA, 1999,96(5): 2110-2115.
10Whang Y E, Wu X, Suzuki H, et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression[J]. Proc Natl Acad Sci U S A, 1998,95(9): 5246-5250.
