体外受精-胚胎移植技术在常规超排卵304个治疗周期中的应用

Analysis of 304 cycles in vitro fertilization and embryo transfer

目的:分析304个常规体外受精与胚胎移植(IVF－ET)超排卵治疗周期资料。方法:使用Buserelin/Metrodin－HP/HCG方案或Decapeptyl/Metrodin－HP/HCG方案超排卵、监测卵泡发育及经阴道超声引导下穿刺取卵、精子优选、体外受精－胚胎移植与黄体期支持等过程。结果:总获卵率86．45%,平均每周期获卵9个,受精率７５．８%,卵裂率96．4%。268个胚胎移植周期中83例获临床妊娠,临床妊娠率31．5%,其中5例流产;河南省首例常规试管婴儿于1999年6月23日顺利分娩,至2000年11月已分娩43例58个婴儿,１例早产死亡,另有35例在妊娠中。结论:作者建立的常规体外受精－胚胎移植技术用于治疗女性原因的不孕症是可靠、有效的。

Aim: To analyze the controlled ovarian hyperstimulation treatment data of 304 routine IVF-ET cycles. Methods: Hyperstimulating with the use of Buserelin/Metrodin-HP/HCG or Decapeptyl/Metrodin-HP/HCG protocol, Monitoring the growth of follicles and performing oocytes aspiration transvaginally with an ultrasound-guided needle. Optimizing sperms and supporting luteal phase ect. Results: The total rate of retrieving ova was 86.45% .Nine ova were retrieved per cycle in average. Fertilization and cleavage rates were 75.8 % and 96.4 % , respectively. A total of 83 clinical pregnancies were obtained from 268 ET cycles in which 5 early miscarriages occurred. The first IVF-ET infant in Henan Province was delivered smoothly on June 23th 1999,58 infants of 43 cases had been delivered successfully till November 2000, of which there was 1 premature delivery and death, and the other 35 pregnancies were ongoing. Conclusion: The technology of routine IVF-EF is reliable and effective for curing the infertility caused by female factors.