中枢性尿崩症72例临床分析

Central Diabetes Insipidus: An Analysis of 72 Cases

目的 探讨中枢性尿崩症 (CDI)的临床表现、病因诊断与治疗的关系。方法 对 72例CDI患者进行回顾性分析。结果 磁共振成像 (MRI)可观察到鞍区微小占位性病变及垂体柄的异常改变、垂体后叶信号的变化。 4例口服弥凝片者全部有效 ,62例采用双氢克尿噻联合卡马西平或安妥明治疗者有效率达 92 %。结论 MRI在CDI病因诊断中起重要作用 ;

Objective\ To explore central diabetes insipidus (CDI) in terms of clinical manifiestations and diagnoses and relations to CDI treatment.Mehtods\ A retrospective analysis was made of admission data of 72 CDI cases.Results\ A minute space occupying lesions in the region and abmornally altered hypophyseal lug were observed with the help of MIR. Minirin orally taken was found effective in all the 4 minirin treated cases, while effetiveness of 92% was achieved in the 62 cases which were treated either with hydrochlorothiazide and carbamazepine combined or with clofibrate.Conclusion\ MRI is important to the etiological diagnosis of CDI, whose symptoms could be controlled by using hormone replacement or non hormonal therapy.