TRANILAST ~1H、^(13)C NMR谱分析及其结构的鉴定

~1H, ^(13)C NMR SPECTRAL ANALYSIS AND STRUCTURAL IDENTIFICATION OF TRANILAST

本文用COSY,CHCOR等二维核磁共振技术对TRANILAST,2[]3-(3.4-二甲基苯基)1-氧代-2-丙烯基]氨基]苯甲到进行了~1H、^(13)C NMR谱数据分析及归属,并结合^(13)C弛豫时间T_1 及变温实验对合成产品进行了结构鉴定.

In this paper, HomoCOSY and Hetero-CHCOR 2D NMR techniques were used to analyze and assign the 1H and 13C NMR spectra of Tranilast, 2- [ [3-( 3, 4-Dinethoxy-phcnyl) -1 - oxo - 2 - propenyl ] amino ] benzoic acid. 13C relaxation times (T1) and variable temperature experiments were used also to identify the structure of the synthesized title compound. Simulated proton spectrum was used to confirm the results.