丽珠得乐对急性脑卒中病人应激性粘膜病变的预防作用研究

Prevention Effect to Stress of Gastric Mucosa Affection Treated with Livzon Dele in Patients with Acute Cerebral Apoplexy

目的:为了探讨丽珠得乐对急性脑卒中病人应激性胃粘膜病变的预防作用。方法:264例急性脑卒中病人在常规脱水利尿、对症支持治疗的基础上,按入院先后随机分为预防组和对照组。预防组128例给予丽珠得乐1粒qid口服或鼻饲,对照组136例未加用制酸药或胃粘膜保护剂分别观察呕血和便血情况,并监测胃液的pH值,连续14d。结果:预防组胃粘膜病变19例,发生率为14.8％,因溃疡出血死亡2例,死亡率为10.5％,明显低于对照组的51例(37.5％)和16例(31.4％),统计学处理差异显著(P<0.05)。结论:丽珠得乐对急性脑卒中病人应激性胃粘膜病变有确切的预防作用。

Objective: To observe the prevention effect to stress of gastric mucosa affection treated with Livzon Dele in patients with acute cerebral apoplexy. Methods: 264 patients with acute cerebral apoplexy were randomly divided into 2 groups. The basic treatment was similar in 2 groups. The prevention group of 128 cases were given Livzon Dele 1 particle oral or oral by nose, qid, the control group of 136 cases were not given the drugs of safeguard of gastric mucose and others. We observed the istance of haematemesis and had blood in their stool and monitored the value of PH in gastric juice,runed 14 days. Results: The rate of gastric mucosa affection and death of stress ulcer in the prevention group was 14.8%(19cases) and 10.5%(2cases),the rate of gastric mucosa affection and death of stress ulcer in the contral group was 37.5%(51cases) and 31.4%( 16cases). There was significant difference of the rate of gastric mucosa affection and death of stress ulcer between the prevention group and the contral group(P<0.01 ). Conclusion: Livzon Dele is good for prevention of stress of gastric mucosa affection in patients with acute cerebral apoplexy.