丙型肝炎病毒感染者自身抗体检测及意义

DETECTION OF AUTO-ANTIBODIES IN HCV CARRIERS AND ITS SIGNIFICANCE

①目的 探讨丙型肝炎病毒 (HCV)感染与自身抗体之间的关系。②方法 对 4 4例抗HCV IgG阳性病人血清进行抗核抗体 (ANA)、类风湿因子 (RF)及抗可提取性核抗原 (ENA)抗体检测 ,并同时检测谷丙转氨酶(ALT)和谷草转氨酶 (AST)。③结果 抗HCV阳性病人ANA ,RF和抗ENA抗体的阳性率分别为 2 7.3% ,2 5 .0 %和 31.0 % ,总的自身抗体检出率为 4 5 .0 % ,与对照组比较差异有显著性 (χ2 =4 .2 0～ 15 .18,P <0 .0 5 ) ;HCV感染病人ANA和RF阳性与阴性者之间AST含量比较差异无显著性 (t =1.4 5 ,t′ =1.2 1,P >0 .0 5 ) ,ANA阳性者与ANA阴性者之间ALT含量比较差异亦无显著性 (t=1.18,P >0 .0 5 ) ,RF阳性和阴性者ALT含量比较差异有显著性 (t′ =4 .75 ,P <0 .0 1)。④结论 HCV感染可触发机体自身免疫反应 ,HCV感染者定期检测RF有助于监测病情的活动性。

Objective\ To explore the relationship of hepatitis C virus(HCV) infection and auto antibodies. \ Methods Sera of 44 patients with positive anti HCV IgG antibodies were tested for antinuclear antibodies(ANA), rheumatoid factor(RF) and anti extractable nuclear antigen antibodies(anti ENA) as well as for ALT and AST. \ Results\ The positive rates of ANA, RF and anti ENA of antibodies in patients with positive anti HCV were 27.3%, 25.0% and 31.0% respectively. The total detected rate of auto antibodies was 45.0%, the difference was significant as compared with the controls ( χ 2=4.20-15.18,P <0.05). The difference of AST levels between positive and negative ANA,RF in patients with positive HCV was not significant ( t=1.45,t′=1.21,P >0.05). The difference of ALT between ANA positive and ANA negative patients was not significant either ( t= 1.18 ,P >0.05), but the difference was significant between RF positive and RF negative patients ( t′=4.75,P <0.01). \ Conclusion HCV infection may bring on auto immune reaction, a regular detection of RF in HCV infection is helpful to monitor the activity of the disease.