摘要
①目的 探讨骨肉瘤病人雌激素受体 (ER)、孕激素受体 (PR)的表达与其临床表现及预后的关系。②方法 结合临床资料及随访结果对 6 5例骨肉瘤病人ER ,PR表达情况进行回顾性分析。③结果 不同性别、年龄、发病部位的骨肉瘤病人ER ,PR表达的阳性率无显著性差异 (χ2 =0 .5 92～ 2 .2 4 2 ,P >0 .0 5 )。临床无转移、存活时间长的骨肉瘤病人ER ,PR表达的阳性率高于临床有转移、存活时间短者 ,差异有显著性 (χ2 =4 .0 7～ 11.85 ,P <0 .0 5 )。④结论 骨肉瘤病人ER ,PR阳性率检测可为骨肉瘤生物学行为。
Objective\ To investigate the relationship between ER,PR expression and clinical characteristics as well as prognosis of osteosarcoma.\ Methods\ The clinical materials and follow up results of 65 cases of osteosarcoma were evaluated retrospectively for the expression of ER and PR in osteosarcoma. \ Results\ There were no significant differences of ER, PR expression among different sex, ages and tumor sites( χ 2=0.592-2.242,P >0.05). The positive rates of expression of ER and PR in the sections from osteosarcoma with no metastasis, and the patients with longer survival time were higher than those in the tumor with opposite conditions. The differences had statistical significance ( χ 2=4.07-11.85,P <0.05).\ Conclusion\ The detection of expression of ER and PR may provide rationale for biological behavior and hormonal therapy of osteosarcoma and prognostic assessment of the patients.
出处
《青岛大学医学院学报》
CAS
2002年第1期64-65,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
骨肉瘤
雌激素受体
孕激素受体
预后
osteosarcoma
receptors, estrogen
receptors, progesterone
prognosis
