泰兴市食管癌、胃癌和肝癌遗传流行病学调查

Evaluation of Segregation Ratio and Hereditability of Esophageal Cancer,Gastric Cancer, Liver Cancer in Taixing County

目的 研究遗传因素在食管癌、胃癌和肝癌发生中的作用。方法 通过遗传流行病学病例对照研究 ,对泰兴市 489个家系(食管癌先证家系 13 2个 ,胃癌先证家系 79个 ,肝癌先证家系 80个 ,对照家系 198个 ) ,应用Li-Mantel和Falconer方法进行分离比及遗传度的估算。结果 泰兴市食管癌、胃癌和肝癌的分离比分别为 0 0 83 9、0 12 0 6和 0 12 71,明显低于 0 2 5 ;遗传度分别为 18 84%(男性 2 2 6% ,女性 14 69% )、2 1 42 % (男性 18 2 3 % ,女性 3 1 5 3 % )和 3 5 74% (男性 3 0 5 6% ,女性 5 4 90 % )。结论 遗传因素在泰兴市食管癌、胃癌和肝癌的发病中有一定的作用 。

Objective To study the effect of genetic factors on the occurrence of esophageal cancer,gastric cancer and liver cancer.Methods A genetic epidemiological case-control study with 489 pedigrees(esophageal cancer 132, gastric cancer 79, liver cancer 80 and 198 controls) was carried out to estimate the segregation ratio and hereditability (h 2) of esophageal cancer,gastric cancer and liver cancer by the methods of Li-Mantel-Gart and Falconer, respectively.Results The segregation ratio of esophageal cancer, gastric cancer and liver cancer was 0.0839, 0.1206 , 0.1271 respectively.These results were significantly lower than 0.25, and the genetic model belonged to polnged to polygenetic.The h 2 of esophageal cancer, gastric cancer and liver cancer was 18.84%(22.6% for male, 14.69% for female),21.42% (18.23% for male and 31.53% for female),35 74%(30.56% for male, 54.90% for female) respectively.Conclusions The genetic factor is one of the risks for esophageal cancer, gastric cancer and liver cancer, but not a main risk.