摘要
目的 :探讨益肝康对实验性肝纤维化大鼠肝细胞损伤的保护作用。方法 :采用 4 0 % CCl4 皮下注射制备大鼠实验性肝纤维化模型 ,与秋水仙碱对照 ,观察益肝康对肝功能、肝脏组织病理变化和超微结构变化的影响。结果 :益肝康能明显改善实验性肝纤维化大鼠的肝功能 ,提高血清白蛋白 (Alb)、减轻肝细胞脂肪变性和坏死。血清丙氨酸转氨酶 (AL T)、Alb和血清球蛋白 (Glb)的变化 ,与对照组比较差异有显著性意义 (分别为 P <0 .0 1,P <0 .0 5 ,P <0 .0 5 )。益肝康组大鼠肝组织的脂肪变性程度较秋水仙碱组明显减轻 ,脂肪变性积分分别为 2 .0 0± 1.36和 2 .75± 0 .6 5 (P <0 .0 5 ) ;电镜观察表明益肝康对实验性肝纤维化大鼠肝细胞线粒体等细胞器的损伤具有保护作用。结论 :益肝康对 CCl4 损伤性肝细胞有保护作用 ,可改善肝功能 。
Objective:To observe the preventive effect of Yigankang on hepatocytes of rats with experimental hepatic fibrosis induced by CCl4 and the change of the ultrastructure. Methods:The Wistar rats were randomly divided into four groups: normal control group (group A), hepatic fibrosis model group (group B), colchicine group (group C) and Yigankang group (group D). Experimental hepatic fibrosis model of rats was induced by 40 % CCl4 through subcutaneous injection,twice a week for 10 weeks. Groups C and D were treated with cholchicine and Yigankang respectively from the beginning of CCl4 injection. Liver function, histological change and ultrastructure were examined at the end of the experiment.Results:Liver function, hepatic histological change and ultrastructure were more significantly improved in group D than those in group C. The degree of steatosis was significantly decreased in group D (P<0.05). Conclusion: Yigankang might protect hepatocytes, mitochondria from the injury induced by CCl4 and improve liver function.
出处
《中国中西医结合消化杂志》
CAS
2002年第2期76-78,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
河北省中医局中西医结合基金资助项目 (No.2 0 0 0 0 1)
