健脾益肠散和固本保元腹袋治疗溃疡性结肠炎的临床研究

Clinical Study on Treatment of Ulcerative Colitis with the Powder of Invigrating Spleen and Benefiting Bowel and the Medicine Bag of Strengthening Kidney Energy and Protecting Primordial Energy

目的 :探讨用自拟健脾益肠散和固本保元腹袋治疗溃疡性结肠炎 (U C)的作用机制。方法 :将 UC患者115例随机分为 4组 :治疗 1组用中药健脾益肠散口服和固本保元腹袋敷脐治疗 ;治疗 2组单用健脾益肠散口服 ;治疗 3组单用固本保元腹袋敷脐 ;对照组病情轻者用柳氮磺胺吡啶 (SASP) ,中重度加用泼尼松。共治疗 3个疗程。治疗结束后观察各组血小板数量、血清白蛋白、免疫球蛋白、补体 3、4 (C3、C4 )含量的变化。结果 :治疗各组与对照组临床疗效、血小板、C3、C4、血清白蛋白、免疫球蛋白等比较 ,差异有显著性意义 (P <0 .0 1,<0 .0 5 ) ;治疗 1组与其他各治疗组比较 ,差异亦有显著性意义 (P <0 .0 1,<0 .0 5 )。结论 :初步证实两种方法均能迅速起到缓解临床症状 ,改善机体的免疫功能 。

Objective:To explore the mechanism of powder of invigrating spleen and benefiting bowel (PISBB) and medicine bag of strengthening kidney energy and protecting primordial energy (BSKPP) in the treatment of ulcerative colitis. Methods: One hundred and fifteen patients were randomly divided into four groups. The patients in group I took PISBB and covered their navels with BSKPP. The patients in group Ⅱtook PISBB while the patients in group Ⅲ just covered their navels with BSKPP. The patients with slight symptoms in group Ⅳtook SASP, while the patients with intermediate or severe symptoms took SASP combined with prednisone. The platelets, serum albumin,immunoglobulin, complements C3 and C4 in the four groups were observed after three treatment courses.Results:There was significant difference in the therapeutic effects, platelets, complements C3 and C4, serum albumin, immunoglobulin between the control group and all the treatment groups (P<0.01 or<0.05). In addition, significant difference was found between group I and the other two treatment groups (P<0.01 or <0.05). Conclusion: Both two therapeutic methods can rapidly relieve the patients' symptoms, improve the immunity and accelerate the healing of the ulcers.