不同剂量垂体后叶素在治疗食管静脉曲张破裂出血中的疗效观察

Observation of Vasopressin with Different Dose on Treatment of Esophageal Variceal Hemorrhage

目的 :比较不同剂量的垂体后叶素在治疗食管静脉曲张破裂出血中的效果。方法 :86例患者随机分成两组 ,第 1组以垂体后叶素 0 .2 u/ min速率持续静脉滴注 ;第 2组以 0 .4u/ min持续静脉滴注 ,比较两组的初始止血率、完全止血率、再出血率、副反应发生率及病死率。结果 :0 .4u/ min组的初始止血率高于 0 .2 u/ min组 ,但前者副反应发生率亦显著高于后者 (P<0 .0 5)。而完全止血率、再出血率及病死率并无统计学差异 (P>0 .0 5)。结论 :应用垂体后叶素治疗食管静脉曲张破裂出血时 ,迅速达到有效血浓度有助于早期止血 ,维持治疗中进一步增加剂量并不能提高止血率。

Objective:To observe the effects of vasopressin on treatment of esophageal variceal hemorrhage.Methods:86 patients were divided into two groups randomly,Group Ⅰ:Vasopressin in 0.2u/min,Group Ⅱ:Vasopressin in 0.4 u/min,in continues intravenous infusion.The frequency of initial control,completely control,rebleeding,complications,and mortality,were compared.Results:The initial control was significantly more frequently in vasopressin with 0.4u/min than in 0.2u/min.But major complications were more common in 0.4u/min than in 0.2u/min,and there were no significant differences in complete control,rebleeding and mortality between the two groups.Conclusions:Reaching the efficiency concentration rapidly can help to control bleeding earlier.But additional increases in the infusion rate dose not result in a further increase in complete control,and dose not result in a further decrease in rebleeding and mortality,too.