9-(4-乙氧羰基苯氧基)-6,7-二甲氧基-1,2,3,4-四氢吖啶盐酸盐对小鼠学习记忆功能的影响

Effects of 9-(4-Ethoxycarboxylyphenoxy)-6,7-dimethoxy-1,2,3,4-tetrahydro acridine on learning and memory ability in mice

目的 :研究 9 (4 乙氧羰基苯氧基 ) 6 ,7 二甲氧基 1,2 ,3,4 四氢吖啶盐酸盐 (EDT)对小鼠记忆功能的影响。方法 :采用小鼠跳台法和Y 型迷宫法 ,观察EDT对小鼠学习记忆功能的影响。结果 :EDT2 .5、5、10mg·kg- 1灌胃 5d ,对东莨菪碱、亚硝酸钠和乙醇致小鼠记忆获得、巩固及再现障碍均有不同程度的改善作用。结论

AIM: To study the effects of 9 (4 Ethoxycarboxylyphenoxy) 6,7 dimethoxy 1,2,3,4 tetrahydro acridine (EDT) on learning and memory abilities. METHODS: The step down test and Y maze test were adopted in this study. RESULTS: EDT ( 2.5 , 5, 10 mg·kg -1 , ig× 5 d ) dose dependently improved the impairment of memory acquisition, memory consolidation and memory retrieval induced by scopolamine, NaNO 2 and alcohol in mice. CONCLUSION: EDT can improve learning and mermory ability in mice.