阿尔茨海默病和多发梗死性痴呆患者脑影像学改变与认知水平关系的分析研究

To Clarify the Relation between the Change of the Brain Imaging and Cognitive Level about Alzheimer' s Disease and Multi - infarct Dementia

目的 研究AD和MID患者脑影像学改变与认知障碍之间的关系。方法 调查134例门诊和住院AD和MID患者,测定脑CT9项指标和MMSE11项因子。结果 AD组三、四脑室、基底池、外侧裂、前后角、脑沟及侧脑室的宽度大于MID组,时间地点定向力、语言即刻记忆、注意和计算及图形描画等5项因子分明显低于MID组;AD组三、四脑室、前角和侧脑室宽度分别与地点定向、注意计算、阅读和语言理解因子分呈显著负相关;MID组后角、三脑室、侧脑室及脉络丛球部宽度分别与时间定向、阅读理解及图形描画因子分呈显著负相关。结论 AD患者脑室系统扩大和认知损害程度比MID患者严重而广泛。

Objective To clarify the relation between the change of CT and cognitive impairment in Alzheimer's disease(AD) and Multi - infarct dementia(MID). Methods 134 cases of AD and MID in clinic and inpatient were investigated with 9 items of CT and 11 scores of MMSE. Results The breadth of the third,forth ventricle,the basilarsulcus,the lateral fissure, the anterior and posterior horn, the grooves and the lateral ventricle in AD were more larger than in MID,It showed lower scores in the temporal and site orientation language and recent memory,attention and calculation and drawing in AD than in MID. There was significant negative correlation in AD between the breadth of third, forth ventricle, the anterior horn, lateral ventricle and site orientation scores, attention, calculation, reading, language and comprehension; In MID, There was significant negative correlation between the breadth of the posterior horn, the third, the lateral ventricle, the choroid plexus and the scores of temporal comprehension and drawing. Conclusions The ventricular enlargement and cognitive impairment were more serious and extensive in AD than in MID.