神经端侧吻合术对喉返神经损伤修复的研究

An experimental study on repairring recurrent laryngeal nerve injuries by latero - terminal neurorrhaphy in rats

目的研究神经端侧吻合术修复喉返神经损伤的效果及临床应用价值。方法 60只SD大鼠被分为三组,实验组为神经端侧吻合组,切断右侧喉返神经,将其远断段与左喉返神经端侧吻合;对照组为神经端端吻合组,切断右侧喉返神经后立即行神经端端吻合;正常组不做处理。术后1、3个月利用纤维喉镜及神经肌电图观察声带活动及神经再生情况。结果术后1个月两种方法手术效果差异有显著性意义(p<0.05)。术后3个月两种方法手术效果差异无显著意义(p>0.05)。结论神经端侧吻合术手术效果与神经端端吻合术相似,为喉返神经修复术提供一种新的手术方法。

Purpose To investigate the effect and the clinical value of latero - terminal neurorrhaphy to repair recurrent laryngeal nerve. Methods 60 SD rats were divided into three groups. In the experimental group, right recurrent laryngeal nerves were incised and anastomosed to left recurrent laryngeal nerve by means of latero - terminal neurorrhaphy. In the contral group, right recurrent laryngeal nerves were incised and sutured immediately by means of end - to - end nerve anastomosis. In the normal group, rats were not treated by any procedure. One to three months later, 10 rats from each group were examined for vocal cord movement and nerve regeneration by using fibrolaryngoscope and nerve electromyography. Results One months after operation, the effect of latero- terminal neurorrhaphy had significant difference,compared with the control group (p < 0.05) .Three months after operation, this effect of latero - terminal neurorrhaphy had no significant difference,compared with the control group (p > 0.05). Conclusion The latero - terminal neurorrhaphy has a similar treatment effect, compared with the end-to-end nerve anastomosis. This microsurgical technigue provides a new method for reparring recurrent laryngeal nerve.