摘要
①目的 探讨小剂量尿酸氧化酶治疗急性脑梗死的效果。②方法 将 10 6例急性脑梗死病人随机分为治疗组 5 6例 ,对照组 5 0例。对照组应用脱水剂、活血化淤、脑保护剂及抗凝剂等治疗。治疗组在对照组的基础上加用小剂量尿酸氧化酶治疗。③结果 在治疗后 2 4h ,治疗组与对照组的临床评分差异无显著性 (F =2 .17,P >0 .0 5 )。治疗后 7d ,30d临床评分 ,两组差异有显著性 (F =4 .6 6 ,q =12 .11,9.87,P <0 .0 5 ;F =6 .2 3,q =17.83,11.91,P <0 .0 5 ) ;6h以内与 7～ 2 4h溶栓治疗在 7d ,30d的临床评分也有显著性差异 (q=7.2 9,8.16 ,P <0 .0 5 )。④结论 小剂量尿酸氧化酶治疗急性脑梗死在临床上有一定的疗效 ,并且安全、方便。溶栓时间越早效果越好。
Objective\ To study the effects of urokinase on acute cerebral infarction . \ Methods\ 106 patients with acute cerebral infarction were randomly divided into Treated Group (56 cases ,regular therapy plus urokinase) and Control Group (50 cases , regular therapy ) .\ Results\ 24 hours after the treatment, the differences of clinical score between the two groups were not significant ( F=2.17, P >0.05) . The results showed that the difference of clinical score was significant after 7 and 30 day treatment of the two groups ( F=4.66, q=2.11, 9.87, P<0.05; F=6.23, q=17.83, 11.91, P <0.05) . The clinical score of thrombolytic therapy 7 and 30 days after the treatment showed significant difference for the patients treated within 6 hours as compared with those within 7-24 hours of the onset( q=7.29, 8.16, P <0.05). \ Conclusion\ Small dose of urokinase is effective, safe and simple clinically for acute cerebral infarction . The sooner use of urokinase, the better effect will be .
出处
《齐鲁医学杂志》
2002年第1期39-40,共2页
Medical Journal of Qilu
关键词
脑梗死
尿酸氧化酶
血栓溶解
cerebral infarction
urokinase
thrombolytic therapy
