双戊烯对酮康唑透皮吸收促进作用

The enhancement effect of dipentene in the transdermal absorption of ketoconazole

目的 :研究双戊烯的透皮促进作用。方法 :采用自制透皮扩散装置。以离体小白鼠背部皮肤为透皮屏障 ,紫外分光光度法测定含不同浓度双戊烯和氮酮对酮康唑的促透效果。结果 :不同浓度促进剂对酮康唑的促透效果顺序为 3%双戊烯 >2 %双戊烯 >3%氮酮 >1%双戊烯。结论 :实验证明 ,3%双戊烯对酮康唑具有较好的促透作用 ,与其它浓度的双戊烯和不同浓度的氮酮相比具有显著性差异 (P <0 .0 5 )或极显著性差异(P <0 .0 1)

OBJECTIVE:To study the enhancing effect of dipentene in the transdermal absorption of ketoconazol. METHODS:The diffusion of ketoconazole acrossed excised mouse skin was determined in vitro using the side-by-side diffusion cells,to compare the enhancement effect of dipentene with azone at difference concentrations in the transdermal absorption of ketoconazole. RESULTS: The sequence of enhancements at difference concentrations of dipentene are as follows: 3%dipentene>2%dipentene>3%azone>1%dipentene. CONCLUSION:It was showed that various concentrations of transdermal enhancers could promote absorption of ketoconazole in different degrees and 3% dipentene was the most effective.