利巴韦林片的处方优化

Prescription optimize of ribavirini tablets

目的 :筛选利巴韦林片的最佳处方。方法 :考察糊精、羧甲基淀粉钠、微晶纤维素和低取代羟丙基纤维素对利巴韦林片的质量影响。结果 :所筛选的适宜润湿剂为 75 %乙醇 ,L -HPC和微晶纤维素的最佳用量分别为 10 %和 15 %。按照最佳处方制备的利巴韦林片硬度和外观大为改善。结论 :本法处方合理 ,工艺简单 。

OBJECTIVE:To obtain the optimum prescription of ribavirini tablets METHODS:The effect of dextrin CMS-Na microcrystalline cellulose and L-HPC on the quality of ribavirini tablets were studied RESULTS: The optimum miistening agents is 75% alcohol, and the optimum amount of L-HPC and microcrystalline cellulose are 10% and 15% respectively Ribavirini tablets prepared with this optimum prescription was much better in terms of hardness and surfaces CONCLUSION:The method is reasonable, and the ribavirini tablets were suitable for clinical use