1Honkoop P,De-Man RA,Zondervan PE,et al.Histological improvement in pattents with chronic hepatitis B virus in fection treated with lamivudine. Liver . 1997
2Marinos G,Naoumov NV,Wdriams R.et aL Impact of com plete inhibition of viral replication on the celluLlar immune response in chronic hepatitis B virus infection. Hepatology . 1996
3Melegnri M,Scaglioni PP,Wands JR,et al.Hepatitis B virus mutants with 3TC and famciclovir administration are repli cation defective. Hepatology . 1998
4Multimer D,Naoumov NV,Honkoop P,et al.Combination alpha-interferon and lamivudine therapy for alpha-inter-feron-resistant chronic hepatitis B infection :results of a pi lot study. Journal of Hepatology . 1998
5Lai CL,Chien RN,Leung NWY,et al.A one-year trial of lamivudine for chronic hepatitis B. The New England Journal of Medicine . 1998
6Niesters HGM,Honkoop P,Haagsma EB,et al.Identification of more than one mutation in the hepatitis B virus poly merase gene arising during prolonged lamivudine treatment. The Journal of Infectious Diseases . 1998
7Omata M.Treatment of chrorilc hepatitis B infection. The New England Journal of Medicine . 1998
3Yao FY,Terrault NA,Freise C,et al.Lamivudine treatment is beneficial in patients with severely decompensated cirrhosis and actively replicating hepatitis B infection awaiting liver transplantation:a comparative study using a matched,untreated cohort[J].Hepatology 2001,34(2):411～416
4Villeneuve JP,Condreay LD,Willems B,et al.Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B[J].Hepatology 2000,31(1):207～210
5Lok A S,Lai C L,Leung N,et al.Long-term safety of lamivudine treatment im patients with chronic hepatitis B[J].Gastroenterology,2003,125 (6):1714～ 1722
6Liaw Y F,Sung J J,Chow WC,et al.Lamivudine for patients with chronic hepatitis B and advanced liver disease[J].N Engl J Med,2004,351 (15):1521～1531
