肝硬化门脉血流动力学与一氧化氮、内皮素

The relationship of portal hemodynamics to nitric oxide and endothelin levels in patients with liver cirrhosis.

探讨肝硬化患者门脉血液动力学与血中 ＮＯ、ＥＴ的相互关系。４８例肝硬化门脉高压患者（代偿期 １８例，失代偿期３０例）及３２例正常人作为研究对象，应用双功多普勒测定门、脾静脉血流量（ＰＶＢＦ＆ＳＶＢＦ），同步测定血中ＮＯ，ＥＴ的水平，分析ＰＶＢＦ、ＳＶＢＦ与ＮＯ、ＥＴ的相关性。门脉系统高血流动力学改变存在于肝硬化门脉高压发病的始终，其形成原因可能在于体内扩血管活性物质ＮＯ的生成增多，及机体对ＥＴ等缩血管物质的敏感性下降，对临床治疗有指导意义。

To study the relationships of portal hemodynamics to vasoactive substances - nitric oxide (NO) and endothelin (ET) in cirrhosis patients, 48 patients with liver cirrhosis (LC) and 32 normal controls (NC) were studied, including 18 patients with compensated LC and 30 patients with decompensated LC. Portal venous and splenic venous blood flow (PVBF and SVBF) were measured by color duplex doppler ultrasonography, and the blood coucentrations of ET and NO were detected. After analyzing the correlation between PVBF and SVBF to NO(ET), the results suggest that protal hy- perdynamic changes, which exist in cirrhosis patients from beginning to the end, were possibly due to the high NO level and the low sensitiving to ET, and it is useful for the clinical treatment.