肝乐宁、肝细胞生长素与G-I治疗重型乙型肝炎的疗效比较

Therapy of severe hepatitis B with Gan Le Ning, HGF and G-I.

为了比较三组药物的疗效，将重型乙型肝炎１０３例，随机分为３组，三组均采用综合基础治疗，Ａ组３２例加用肝乐宁０．４－１．０于糖水中滴注，每日一次，Ｂ组３５例加用肝细胞生长素４０ｍｇ－１００ｍｇ；Ｃ组加用胰高血糖素１ｍｇ联合胰岛素８ｕ－１０ｕ（Ｇ－Ｉ），用法均同Ａ组。观察疗效、副作用及肝功能改善情况。结果三种药物临床总有效率分别为５０％、５７％和４４％，统计学处理差异无显著性。血清胆红素下降Ｃ组较Ａ组和Ｂ组明显（Ｐ＜０．０５及 Ｐ＜０．０１）。Ａ、Ｂ二组副作用不明显，Ｃ组不良反应较多。ＡＬＴ、ＡＬＢ及ＰＴ的变化三组无显著差异。

To evaluate effects of Gan le ning, HGF and G - I therapy for severe hepatitis B, 103 patients were randomized into three groups. Group A(n = 32) was treated with Gan le ning 0. 4 - 1 .0 v gtt q. d, and group B(n = 35)with Hepato- cyte growth factor (HGF) 40mg - 100mg v gtt q. d, and group c(n = 36) with glucagon 1mg - Insulin 8u - 10u (G - I) v gtt q. d. The clinical efficiency rates were 50.0% .57 .0% .44.0% respectively. There were no significant different among three groups. However, the level of total serum bilirubin (TSB) of group c decreased more significantly than that of Group A and B (P < 0. 05) and P < 0. 01). Side effects of Group C were more severe than that of other groups.