一氧化氮对心肌收缩功能的影响

Effects of Nitric Oxide on Myocardial Contraction Function.

心肌细胞合成的NO被认为是调节心肌收缩功能的重要分子 ,本文综述了NO对心肌收缩功能的影响、NO作用机理以及诱导型一氧化氮合酶的表达与活性调控等的研究进展。最近的研究表明NO对心肌的收缩起一种双向的调节作用 :低浓度时促进心肌的收缩 ,高浓度时则起抑制作用。诱导型一氧化氮合酶的诱导表达往往导致心肌的收缩功能下降。

Nitric oxide(NO) produced by myocardial nitric oxide synthase has been implicated as a modulator of myocardial contracion This paper reviewed the reports on myocardial contraction modulated by NO,its mechanism,and regulation of expression and activity of iNOS .NO was recently shown to produce biphasic contratile effects on myocardium: augmentation at low levels and depression at high levels.The up regulation of inducible nitric oxide synthase (iNOS) often negatively modulates myocardial function.