无功能胰岛细胞瘤237例分析

Non-functional islet-cell tumor:analysis of 237 cases

目的 了解国内无功能胰岛细胞瘤的临床流行病学资料及其诊治要点。方法 对近 2 0年的国内无功能胰岛细胞瘤的文献报告进行了总结 ,应用“中国生物学医学文献数据库”光盘(1981.1～ 1999.10 ) ,检索无功能胰岛细胞瘤的文献报告。结果 共得到有效文献 6 0篇 ,共报告 2 37例无功能性胰岛细胞瘤。总结了 2 37例无功能胰岛细胞瘤的临床流行病学资料、临床表现、诊断及鉴别诊断、治疗方法及治疗结果。结论 无功能胰岛细胞瘤罕见 ,女性多于男性 ,术前诊断率低 ,恶性无功能胰岛细胞瘤预后较好 ,治疗应更加积极。

Objective To summarize the clinical aspects of nonfunctional islet cell tumor (NIT) reported in Chinese periodicals. Methods Articles in Chinese on NIT were screened from the Chinese Bio Medical Database (1981.1 1999.10). Data of epidemiology, clinical manifestations, diagnosis, defferential diagnosis, and treatment of NIT were analyzed. Results 60 articles and 237 cases of NIT were selected. The female to male ratio was 2.9∶1. Abdominal mass was the most common clinical symptom. It was difficult for the pre operative diagnosis of NIT and differentiation from pancreatic tumor or retroperitoneal mass. The malignant rate of NIT was 35%. The five year survival rate of malignant NIT was 53.1%. Conclusion NIT is rare. It occurres more often in female than in male. The preoperative diagnostic rate is rather low. The prognosis of malignant NIT is favorable. Active treatment is strongly recommended.