氟马西尼治疗急性重度苯二氮类药物中毒的临床研究

Clinical research on flumazenil in the treartment of extensive acute bezodiazepine poisoning

目的探讨氟马西尼治疗急性重度苯二氮艹卓 类药物 (BZDs)中毒的临床价值。方法将急性重度BZDs中毒患者 4 0例随机分为两组 ,氟马西尼组 2 0例 ,常规治疗组 2 0例。疗效评判采用Glasgow～Pittsburgh昏迷深度评定方法和观察者对患者机敏力 /镇静程度评判量表 (OAA/S)指标。结果治疗组经氟马西尼治疗后昏迷深度显著改善 (除 5分钟P <0 0 5外 ,其余P <0 0 1)。以OAA/S指标比较两组疗效差异亦具有显著意义 (P <0 0 1)。结论氟马西尼可作为治疗急性重度BZDs中毒的特效解毒药 ,且疗效稳定 ,无明显毒副反应。

Objective To study the clinical value of flumazenil to treat benzodiazepine poisoning. Methods 40 patients suffered from benzodiazepine were randomly divided into two groups the flumazenil treatment group ( n =20) and control group ( n =20). The mental status of patients were assessed by the therapentic deep Glassgow～Pittsburgh scale and Obser ver's Assessment of Alerness/Sedation Scale (OAA/S). Results The flumazenil treatment group compared with the control group was significantly different (all P <0.01except 5 minutes P <0.05). It also showed significantly different in OAA/S tests. Conclusion Flumazenil with the steady effect could be used as a specific alexiph armic to treat BZDs without serious side effect.