川芎素对大肠癌细胞moser的影响及其与化疗药物的协同作用

Effect of sodium ferlate on moser cells and it's synergetic effect with chemotherapy drugs

目的 探讨中药川芎素对大肠癌细胞的影响及其与多种化疗药物的协同作用。方法 采用MTT法 ,测定川芎素与各种化疗药物对moser细胞的增殖抑制作用以及川芎素与化疗药物协同对moser细胞的增殖抑制作用。用流式细胞仪测定川芎素对moser细胞周期的影响。结果 川芎素可抑制moser细胞增殖 ,并可诱导其凋亡。低浓度的川芎素与化疗药物协同 ,可产生较强的抑制细胞增殖的作用。结论 川芎素具有直接的抗肿瘤作用 。

Objective To investigate the effect of sodium ferlate(SF), a Chinese medicinal herb, on large intestine cancer moser cells and the synergetic effect of SF and chemotherapy drugs. Methods The effect of SF and chemotherapy drugs on moser cells was detected by MTT assay and Flow cytometric cell cycle analysis. Results SF can inhibit the proliferation and induce apoptosis of moser cells . SF in low concentration have synergetic effect with several chemotherapy drugs. Conclusion SF has a direct anticancer effect and can enhance the action of several chemotherapy drugs.