癌基因蛋白c-erbB-2和p21^(ras)在肺癌中的表达及意义

Expression and Significance of Oncogene Protein c-erbB-2 and p21^(ras) in Human Lung Carcinoma

目的 探讨原癌基因c erbB 2和p2 1ras在肺癌形成机制中所起的作用。方法 用免疫组织化学SABC法对原发性肺癌中两种基因表达作一检测。结果 5 5例肺癌中 ,2 2例 (44 % )c erbB 2过度表达 ,2 5例(45 % )p2 1ras过度表达 ,其中 10例小细胞肺癌中均未见两种基因过度表达。c erbB 2基因过度表达与淋巴结有无转移具有明显相关性 (P <0 0 5 )。c erbB 2 ,p2 1ras蛋白表达在肺癌分化程度中呈负相关 (P <0 0 5 )。结论 c erbB 2 ,p2 1ras在肺癌形成和发展中协同作用 。

Objective To investigate the effect of c erbB 2, p21 ras genes in the carcinogenesis of lung cancer. Methods The expressions of c erbB 2, p21 ras oncoprotein in lung cancer were examined immunohistochemically. Results Of 55 cases of primary lung tumors, 22(40%) were positive for c erbB 2 expression and 25 cases (45%) for p21 ras expression. There were no expression of c erbB 2 and p21 ras in 10 small cell lung carcinoma (SCLC). There was significant correlation between expression of c erbB 2 oncoprotein and lymph node metastasis ( P <0 05). The two genes showed coexpression in some of of the lung cancer. There was significant correlation between the expression of c erbB 2, p21 ras and histological grade ( P <0.05). Conclusion c erbB 2 gene interacts with p21 ras gene in the carcinogenesis and development of lung cancer, which has positive effects on prognosis and treatment of lung cancer.\;