嗅鞘细胞移植治疗脊髓损伤临床试验的初步报告

Preliminary Report of Clinical Trial for Olfactory Ensheathing Cell Transplantation Treating the Spinal Cord Injury

目的 开展嗅鞘细胞移植治疗脊髓损伤的临床试验 ,探讨其对脊髓损伤晚期患者是否有帮助脊髓神经功能恢复的作用。方法 取胚胎嗅球 ,消化成单个嗅鞘细胞后 ,培养 2～ 3周 ,然后将其移植到脊髓损伤部位的上下处。共治疗 2 3例伤后时间为 0 5～ 8 5年的脊髓损伤患者 ,其中 19例为完全性脊髓损害 ,4例为不完全性脊髓损害。结果 嗅鞘细胞移植后 2周～ 2个月时随访 ,2 3例患者的脊髓功能均有改善 ,且呈继续改善趋势。

Objective To develop clinical trial for olfactory ensheathins cells (OEC) transplantation treating the spinal cord injury, and to explore whether it would help the patients with spinal cord injury in late time to recover their spinal cord function. Methods Olfactory bulb was got and trypsinized to be single OECs; which were cultured for 2～3 weeks, then transplanted OECs into the upper and lower sites between injury and normal spinal cord. 23 patients with the spinal cord injury were treated half year to eight and half years after injury. Among them 19 patients expressed complete spinal cord injury and other 4 with incomplete spinal cord injury. Results Followed up between 2 weeks and 2 months after OECs transplantation, all 23 patients recover their spinal cord function. And they present the trend of continuing recovery. Conclusion OECs transplantation can help patients with spinal cord injury in late time to recover their spinal cord function.\;