肝疏通胶囊对小鼠免疫功能的影响

The influence of Ganshutong capsule on the immune function of little white mouse

目的 :研究肝疏通胶囊对小鼠免疫功能的影响。方法 :选用ICR小鼠 ,体重 18～ 2 2g ,♀♂兼用 ,随机分成 5个组 ,一个对照组 ,一个左旋咪唑组 (10mg·kg-1)和肝疏通胶囊 3个剂量组 (0 .4,1.0 ,2 .5 g·kg-1)各组均ig给药 ,qd ,连续 7d ,观察预定指标。结果 :肝疏通胶囊 3个剂量组能明显提高小鼠单核巨噬细胞的吞噬功能 ,提高廓清指数 ;明显促进溶血素的产生 ;2 .5 g·kg-1组能促进小鼠的迟发性超敏反应。结论 :肝疏通胶囊有促进细胞免疫和体液免疫的作用 。

OBJECTIVE To investigate the influence of Ganshutong capsule on the immune function of mouse. METHODS Selecting both male and female mouse of ICR strain with body-weight between 18～22 grams, and randomly dividing them into five groups, a contrasting group, a group of medicine levamisol-um (10 mg·kg -1)and three experimental groups with different dosage ( 0.4, 1.0, 2.5 g·kg -1), each group wsa given the medicine by the way of ig. once a day for a week. The results were observed and recorded. RESULTS The cytophagocytesis of the mononeuclear phagocytes were greatly improved in the three experimental groups,enhancing guoting index; and apparently bringing a great advance in the production of haemolysin;the delayed type hypersensitivity (DTH) was promoted in the group with the dosage of 2.5 g·kg -1.CONCLUSIONS Ganshuotong capsule has remarked effects on promoting cellular immunity and humoural immunity and is beneficial for treating chronic hapetitis.