腓肠肌细胞病理形态学改变与DVI病变进展关系研究

Experimental study on the correlation between pathologicomorphologi cal change of gastrocneminus muscle cell and progress of deep venous insufficiency

目的 探讨腓 肠肌细胞细胞病理形态学与原发性深静脉瓣膜功能不全（ＤＶＩ）关系。方法 ＤＶＩ病人按照病情分成三组，每组９人，行腓肠肌及缝匠肌ＨＥ染色及ＡＴＰ酶特殊组织化 学染色细胞形态学定量检测。结果 ＤＶＩ疾病的轻、中度组腓肠肌及 缝匠肌各组间细胞形态学检测差异无显著性，ＤＶＩ疾病的重度组腓肠肌与轻、中度组及缝匠 肌组对照，腓肠肌细胞形态退行性病变明显。结论 随ＤＶＩ病变进展 ，腓肠肌细胞病理形态明显退行性改变，它可能是腓肠肌泵功能衰退和临床症状加重的病理 基础。［

Objective This work aimed at study the rel ationship between the pathologicomorphological change of gastrocneminus muscle cells and deep venous insufficiency (DVI).Methods Patients with DVI in three different stage of developing process are grouped into early t eam?middle team and late team group ,each group consists of 9 cases.HE stain , special ATPase histoenzymic methds was quantitatively employed to study histo chemical cytomorphology of gastrocneminus and musculus sartorius specimens in th ose subjects.Results There is no significant difference of the pathologicomorphological change,either between early-stage group and mid-sta ge group or between early-stage group & mid-stage and control group.But there is significant difference comparing advanced stage group and early-stage group & m id-stage group or between advanced-stage and control group.Conclusion As the process of DVI develops,marked morphological degeneration can be found in gastrocneminus muscle cells.It could be regarded as the pathogenic fundament of impairment of calf muscle pump and development of DVI.