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重症联合免疫缺陷病发病机制和基因治疗的进展 被引量:2

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摘要 免疫缺陷病常出现皮肤病变 ,成为皮肤病学研究的内容之一。近 10年来 ,在重症联合免疫缺陷病分子发病机制和基因治疗研究取得重要进展 ,尤其在 2 0 0 0年 ,采用基因治疗成功治愈X联锁重症联合免疫缺陷病患者 ,被认为是基因治疗具有里程碑意义的发现。
出处 《国外医学(皮肤性病学分册)》 2002年第2期79-81,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
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  • 1Freedberg IM, et al. Fitzpatrick's Dermatology in General Medicie. 5th ed, New york :McGraw-Hill,1999.1401.
  • 2Noguchi M, Yi H, Rosenblatt HM, et al. Intedeukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell, 1993,73(1):147-157.
  • 3Russell SM, Keegan AD, Harada N, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science, 1993,262(5141):1880-1883.
  • 4Jameson JL, et al. Principles d Molecular Medicine . 1st ed , New York :Humana Press In, 1998.249.
  • 5Santisteban I, Arredondo-Vega FX, Kelly S, et al. Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype. J Clin Invest, 1993,92(5):2291- 2302.
  • 6Russell SM, Tayehi N, Nakajima H, et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lyphoid development. Scinece, 1995,270(5237): 797-800.
  • 7Puel A, Ziegler SF, Buckley BH,et al. Defective IL7R expression in T (-) B (+) NK (+) severe combined immunodeficiency. Nat Genet, 1998,20(4):394-397.
  • 8Buckley RH, Schiff SE, Schiff RI, et al. Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med, 1999,340(7):508-516.
  • 9Blaese RM, Culver KW, Miller AD, et al.T lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science, 1995, 270(5235) :475-480.
  • 10Bordignon C, Notarangelo LD. Nobili N, et al. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science, 1995,270(5235):470-475.

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