ER和PR在子宫颈的分布及其与宫颈鳞癌的关系

Expression of estrogen and progesterone receptors in normal cervical tissue and the relation to human cervical squamous cell carcinoma

目的 :检测雌激素受体 (ER)、孕激素受体 (PR)在正常子宫颈的分布 ,并探讨ER和PR的表达状态与宫颈鳞癌的发生发展及预后的关系。方法 :采用SP免疫组化方法对 2 1例正常宫颈 ,40例宫颈上皮内瘤变 (CIN)及 71例浸润性宫颈鳞癌进行ER、PR检测。结果 :正常宫颈ER、PR主要在鳞状上皮、腺上皮及间质细胞核表达 ,且三者表达状态基本一致 ,CIN鳞状上皮及浸润性宫颈鳞癌ER、PR核表达率明显降低。结论 :ER、PR核表达下调或缺失可能是宫颈鳞癌发生的一重要机制。

Objective:To detect Estrogen receptor(ER) and progesterone receptor(PR) expression in normal cervical specimens and cervical squamous cell carcinoma,and study the relationship between ER,PR expression and the malignant progression and prognosis of cervical squamous cell carcinoma.Methods:Immunohistochemical method was used to detect ER and PR expression in 21 cases of normal cervical specimens,40 cases of cervical intraepithelial neoplasm(CIN) and 71 cases of invasive cervical squamous cell carcinoma.Results:To normal cervical specimens,ER and PR express mainly in the nucleus of cervical squamous epithelium,glandular epithelium and stromal cells.But the nucleus expression rate of ER and PR were significantly lower in CIN and invasive cervical squamous cell carcinoma.Conclusion:Expression of ER and PR in cervical squamous cell carcinoma was lower or deficient,which may play an important role in the malignant progression of cervical carcinoma.