2型糖尿病合并大血管病变患者GMP-140、vWF检测的意义

Clinical significance of plasma platelet membrane glycoprotein-140 and von Willebrand factor concentrations measured in diabetes mellitus with macro-vascular disease

目的 :研究 2型糖尿病患者血小板膜糖蛋白 - 140 (GMP- 140 )、血管性血友病因子 (v WF)和血栓形成之间的关系 ,及与糖尿病合并大血管病变之间的联系。方法 :采用酶联免疫吸附双抗体夹心法定量测定 30名糖尿病无并发症、 35名糖尿病伴大血管病变患者 ,35名正常人的血浆 GMP- 140、 v WF水平。结果 :2型糖尿病患者的血浆 GMP-140 ,v WF水平高于正常组 (P<0 .0 1) ,糖尿病伴大血管病变的患者上述变化更显著 (P<0 .0 0 1)。结论 :2型糖尿病患者血管内皮细胞损伤、血小板粘附性和聚集性增加 ,易于形成血栓 ,与大血管并发症有一定因果关系。

Objective:The purpose of this study is to explore the relations among GMP-140,von Willebrand factor(vWF) concentrations and thrombosis,and clinical significance of their measurement in 2-type diabetes mellitus(DM).Methods:GMP-140 and vWF concentrations were measured in 30 patients with DM but without macro-vascular disease and 35 patients with DM complicated macro-vascular disease,and 35 healthy volunteer served as control.Results:GMP-140 and vWF concentrations in DM patients without macro-vascular disease were higher than that in control group(P<0.01).Their levels were more significant in 2-type DM with macro-vascular disease(P<0.001).Conclusion:The results indicate that there are endothelial cell damage and adhere,aggregate of platelets increase in patient with DM,it accelerate the macro-vascular disease to happen.