内地高辛、钠、钾、镁与高血压病胰岛素抵抗的相关性

Correlation among insulin resistance of hypertension and endoxin,Na,K,Mg

目的 :探讨内地高辛及钠、钾、镁在高血压病胰岛素抵抗病理机制中的作用。方法 :测定 30例高血压病患者(EH组 )的空腹血浆葡萄糖 (FPG)、胰岛素 (FINS)水平 ,同时测定血清内地高辛 (EDX)及细胞内 Na+、 K+、 Mg2 +含量并与 2 6例正常血压对照者 (NC组 )作对照。结果 :EH组 FPG、FINS、EDX、Na+水平显著高于 NC组 (P<0 .0 5 ,<0 .0 1,<0 .0 1、 <0 .0 0 1) ,胰岛素敏感性指数 (ISI)、 K+、 Mg2 +显著低于 NC组 (P<0 .0 0 2 ,<0 .0 1,<0 .0 0 1) ;EH组 FINS与体重、体重指数 (BMI)、臀围、 EDX呈显著正相关 (r=0 .5 2 ,0 .35 ,0 .45 ,0 .41;P<0 .0 0 5 ,<0 .0 5 ,<0 .0 1,<0 .0 5 ) ,ISI与体重、BMI、臀围呈显著负相关 (r=- 0 .5 8,- 0 .42 ,- 0 .5 7;P<0 .0 0 1,<0 .0 5 ,<0 .0 1)。结论 :高血压患者血胰岛素水平与内地高辛、肥胖呈显著正相关 (P<0 .0 5～ <0 .0 0 5 ) ;ISI与肥胖呈显著负相关。

Objective:To analyze the correlation among insulin resistance of hypertension and endoxin(EDX),Na +,K +,Mg 2+ .Methods:Fasting plasma glucose(FPG),fasting plasma insulin(FINS),serum EDX and erythrocyte sodium(Na +),potassium(K +),magnesium(Mg 2+ ) levels were measured in 30 patients with essential hypertension(EH) and 16 normotensive controls(NC).Results:When compared with NC group the FPG,FINS,EDX and Na + levels of EH group were significantly higher in EH patients group(P<0.05,<0.01,<0.01?<0.001,respectively),the K +,ISI,Mg 2+ levels of EH group significantly decreased(P<0.002,<0.01,<0.001,respectively).The linear correlation analysis shows the FINS was significantly related to body weight,body weight index,hip and EDX in patients with EH(r=0.52,0.35,0.45,0.41;P<0.005,<0.05,<0.01,<0.05,respectively).The ISI was significantly related to body weight,body weight index and hip in patients with EH(r=-0.58,-0.42,-0.57;P<0.001,<0.05,<0.010,respectively).Conclusion:There is significantly positive correlation among insulin level and EDX,obesity,there is significantly negative correlation between ISI and obesity.