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丙戊酸钠的肝脏毒性及防治 被引量:4

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摘要 本文介绍了丙戊酸钠肝毒性的临床表现为:肝酶增加、血氨升高、抑制凝血、低血糖和酸中毒、微囊状脂肪变性及抑制β氧化;并对其提出了预防和治疗措施。
作者 周庆 喻东山
机构地区 南京脑科医院
出处 《药物不良反应杂志》 2002年第2期93-95,共3页 Adverse Drug Reactions Journal
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同被引文献29

  • 1龙幼敏,雷秀霞,李萍.丙戊酸血药浓度对肝肾功能的影响[J].广州医药,2005,36(5):50-51. 被引量:6
  • 2陈智清,倪龙娟.有效血浓度丙戊酸钠对儿童肝功能的影响[J].浙江医学,2006,28(10):869-870. 被引量:4
  • 3黄静,任榕娜.抗癫癎药物致肝损伤的研究进展[J].实用儿科临床杂志,2007,22(6):465-467. 被引量:19
  • 4V e drine L, Biance N, Souleau B, et al.Agranulocytosis and simultaneous cholestatic janndiice induced by sodium valproate in an elderly woman[J]. Presse Med, 2001,31)(28): 1404.
  • 5廖建湘,路新国,操德智,蒋玉梅,肖志田,李成荣,秦炯.生酮饮食疗法在癫癎治疗中的应用[J].中国当代儿科杂志,2007,9(5):517-520. 被引量:21
  • 6李金恒.丙戊酸血药浓度监测[M].临床治疗药物监测的方法和应用[M].北京:人民卫生出版社,2003:40.
  • 7Jaeschke H, Gores GJ, Cederbatlm AI, et al. Mechanisms of hepatotox- icity [J]. Toxicol Sci, 2002,65 : 166-176.
  • 8王雪,刘民台,王瑜译.癫痫生酮饮食疗[M].北京:人民卫生出版,2009:16.
  • 9Hawkes ND, Thomas GA, Jurewicz A, et al. Non-hepatic hy perammonaemia:animportant,potentially reversible cause of encephalopathy[J]. Postgrad Med J, 2001, 77(913):717-722.
  • 10Segura-Bruna N, Rodriguez-Campello A, Puente V, et al. Valproate-induced hyperammonemicencephalopathy[J]. Acta Neurol Scand, 2006, 114(1): 1-7.

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