过度训练对心肌间质胶原、心肌舒缩性能和AngⅡ变化的研究

RELATION OF INTERMYOCARDIAL COLLAGEN REMODELING TO THE CHANGES OF MYOCARDIAL SYSTOLIC PROPERTY AND ANGIOTENSINⅡON THE OVERTRAINING RATS

目的 :为了研究和探讨过度训练对心肌间质胶原的重塑及其与心肌舒缩性能和AngⅡ变化的关系。方法 :在SD大鼠过度训练模型上对心肌间质胶原形态结构 ,心肌胶原含量 ,心肌局部与循环血中血管紧张素Ⅱ (AngⅡ )含量以及心肌收缩和舒张性能等指标进行了观察测试与分析。结果 :过度训练导致心肌束之间 ,心肌细胞之间 ,尤其是心肌细胞膜上大量胶原纤维过度增粗并成束成网分布 ,心肌细胞被增粗的胶原纤维网包裹。一般训练组与对照组比较 ,心室系数、心肌胶原含量以及心肌局部与循环中AngⅡ等指标均显著性增加P <0 .0 1)。过度训练组与对照组及一般训练组比较 ,上述诸指标均有显著性变化。心肌舒缩性能指标测试表明 ,一般训练组与对照组比较 ,±dp dtmax和±d2 p dt2max均显著性升高 ,T值缩短 ;而过度训练组上述诸指标则显著性降低 ,T值延长 ,与一般训练组比较具有显著性差异。结论 :过度训练导致心肌间质胶原过度增生 ,心肌收缩与舒张功能受损 。

Aim: To investigate the relation of intermyocardial collagen (IMC) remodeling to the changes of myocardial systolic property (MSP) and angiotensinⅡ(AngⅡ)on the overtraining rats.Methods: Morphologic remodeling of IMC and changes of contents of IMC and AngⅡ in myocardium local and circulation,and MSP in SD rat overtraining models were observed and determined by RM-6200 polygraph,Beckman-42 automatic biochemistry analysor,and gamma automatic radio-immunity analyzer and S-570 scanning electron microscope under the conditions. Results: IMC forms a spatial three-dimensional network structure,consisting of collagenous fiber connection among myocardial bundles,cardiac muscle cell group,cardiac muscle cells,endocardium and capillary. There are some regularities in its interlacing.Conclusion: Overtraining could lead to ovterhyperlasia of IMC in myocardial bundles,cardiac muscle cell group,cardiac muscle cell,endocardium and capillary,and serious injury of MSP. The relation closes to remodeling of IMC and MSP and AngⅡ on the overtraining.