小剂量美托洛尔治疗扩张型心肌病充血性心力衰竭疗效评价

Appreciate of Effect on Low Dose Metoprolol in Treating Dilated Cardiomyopathy Congestive Heart Failure

目的 评价小剂量美托洛尔治疗扩张型心肌病心力衰竭的临床疗效和安全性。 方法 将扩张型心肌病心力衰竭 4 0例 ,随机分为治疗组和对照组 ,对照组仅予常规治疗 ,治疗组在常规治疗的基础上加用美托洛尔 ;用超声心动图测定治疗前后左室射血分数 ( LVEF)和左室舒张末内径 ( LVDd) ,取治疗4周后的临床资料进行评价。 结果 治疗组总有效率 81 .8% ,明显高于对照组的 5 5 .6 % (χ2 =4 .71 ,P<0 .0 5 ) ,无严重不良反应 ,心功能、 LVEF、 LVDd治疗前后比较 ,治疗组优于对照组 ,治疗组具有显著或非常显著性差异 ( P <0 .0 5或 P <0 .0 1 )。 结论 小剂量美托洛尔能明显改善扩张型心肌病心力衰竭病人的心脏功能 ,安全有效。

Objective To Appreciate the effect low dose metoprolol on treating of dilated Cardiomyopathy on Congestive heart failure. Method 40 cases with dilaed Cardiomyopathy on Congstive heart failure were randomly diveided into treated group and control group,ALL patients received routine therapy metoprolol plus treated group clinical out comes were evaluated 4 weeks,Latter left Ventricular ejecting fraction(LVEF) and left Ventricular diastasis dialog(LVDd) of echograpny were measured before and after the treatment. Result Clinical efficacy and total rateis 81.8 percent 55.6(χ 2=4.71,P<0.05) treated group obrious side,there found no anverse reactions related to the drug differernces indexes of heart fuaction and LVEF and LVDd were obvious or very obvious(P<0.05 or P<0.01). Conclusion Low dose metoprolol which path way of improve the heart function in patients with obvious side effects and safety.