两种心衰模型大鼠心功能的比较

Comparison of Cardiac Function in Different Animal Models with Cardiac Failure

目的 比较两种心衰模型大鼠心功能的特点。方法 用腹主动脉、下腔静脉穿刺造瘘法及冠脉结扎法建立不同的心衰模型 ,用Doppler超声心动图及心脏称重的方法比较其心功能的各项参数。结果 两组大鼠的相对心脏重量均有所增高。造瘘组射血分数有所下降 ,但心输出量、血压维持正常 ,而冠脉结扎组术后 3周射血分散、心输出量和平均动脉压均明显下降 ,等容舒张期延长。结论 腹主动脉、下腔静脉穿刺造瘘所造成的是高输出量心衰 ,而冠脉结扎法所造成的是低输出量心衰 ,其心衰程度更为严重。Doppler超声心动图为大鼠心功能的检测提供了一种简单、可靠、可随访的无创伤性检查方法。

Objective\ To compare the characteristic of cardiac function in two different congestive heart failure animal models.Methods\ To establish different congestive heart failure animal models with abdominal aortocaval shunts and ligature of the left coronary artery respectively was established in rats. The cardiac function test was with Doppler echocardiography.Results\ All the rats in both groups had developed cardiac hypertrophy.Ejection fraction (EF) of rats with aortocaval shunts decreased,but cardiac output (CO) and blood pressure (BP) in this group maintained normal.While EF,CO and mean artery pressure (MAP) all reduced significantly in ligation rats,IRT increased in this group.Conclusions\ Abdominal aortocaval shunts leads to high output cardiac failure.Cardiac failure resulted from ligation of coronary artery is low output,which is more severe.Doppler echocardiography provides a simple,reliable easy\|follow\|up way to test cardiac function in rat.\;