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早老素基因的研究进展 被引量：2

The Study Advances of Presenilin Gene
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摘要 Alzheimer病又称老年性痴呆病 (AD) ,它是一种涉及多因素发生学、以进行性痴呆为主要临床表现的大脑变性性疾病。在对其发病遗传因素研究中 ,早老素 (Presenilin ,PS)基因突变是近年来研究的热点。PS基因与Alzheimer病的病理进程 ,如与老年斑的形成有关。 Alzheimer's disease(AD)is a neurodegenerative disorder characterized by progressive memory loss and certain neuropathological hallmarks. AD is associated with multifactorial etiology. Among the genetic factors mutant PS genes have been eagerly studied in the recent years. Many studies have shown that PS can accelerate the pathological formation of senile plaque of AD, and that PS is related to both familial Alzheimer's disease (FAD) and sporadic Alzheimer's disease.
作者 张兵林 秦川
机构地区 中国医学科学院中国协和医科大学实验动物研究所
出处 《中国实验动物学杂志》 2002年第2期113-116,共4页 Chinese Journal of Laboratory Animal Science
关键词 阿尔茨海默病 早老素基因 研究进展 Alzheimer's disease Presenilin Gene
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献25

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同被引文献77

  • 1钟远,贾伟平.阿尔茨海默病与2型糖尿病[J].上海医学,2005,28(1):75-76. 被引量：3
  • 2丁新生.重视Alzheimer病的诊治[J].临床神经病学杂志,2005,18(4):241-243. 被引量：17
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  • 8Markram K, Gerardy-Schahn R, Sandi C. Selective learning and memory impairments in mice deficient for polysialylated NCAM in adulthood [ J]. Neuroscience, 2007 ; 144 ( 3 ) : 788-96.
  • 9Polo-Parada L, Bose CM, Plattner F, et al. Distinct roles of different neural cell adhesion molecule ( NCAM ) isoforms in synaptic maturation revealed by analysis of NCAM 180 kD isoform-deficient mice[J]. J Neurosci,2004 ;24(8) :1852-64.
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中国实验动物学杂志
2002年 第2期

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