肺炎链球菌致病机理的最新研究进展

THE NEWEST ADVANCE IN PATHOGENIC MECHANISM OF Streptococcus pneumoniae

肺炎链球菌致病过程包括粘附 ,炎症反应 ,细菌产物的细胞毒作用。阻止肺炎链球菌粘附到宿主细胞受体和定植在粘膜表面 ,是预防其感染的最有效的途径。综述了肺炎链球菌粘附过程的最新研究进展和肺炎链球菌毒力因子及其可能的致病机理 ,对研制新一代疫苗 ,预防和治疗肺炎链球菌感染有重要意义。

The pathogenic process of pneumonia infected by Streptococcus pneumoniae includes adherence, inflammatory reaction, and cytotoxic effect of virulent factors. Therefore, the most effective way to prevent from the infection of Streptococcus pneumoniae is to stop the adherence of it to the host cell. Recent evidences also indicate that the virulent factors play an important role in the pathogenesis of the disease. The newest advance in virulent factors and the possible pathogenic mechanism of Streptococcus pneumoniae was reviewed in this paper. These have important significance in studying new vaccine, preventing from and curing the infection of Streptococcus pneumoniae .\;