5-羟色胺对去甲肾上腺素诱导大鼠心肌肥厚的影响

Effect of 5-hydroxytryptamine on norepinephrine-induced cardiac hypertrophy in rats

目的 了解 5 羟色胺 (5 HT)对去甲肾上腺素(NE)所致心肌肥厚有何影响。方法 大鼠分别ip5 HT 2mg·kg- 1,NE 2mg·kg- 1或NE 2mg·kg- 1+ 5 HT 2mg·kg- 1。每日 2次 ,连续给药 15d ,d 16麻醉 ,颈动脉插管 ,观察累积iv不同剂量 5 HT对平均动脉压和心电图的影响 ,之后处死大鼠 ,观察心重与体重之比。结果 累积iv 5 HT ,NE组和NE + 5 HT组大鼠血压明显升高 ,诱发室速和室颤的鼠数明显增加 ,但该两组间无显著差异。NE组心室重与体重之比明显增加 ,NE + 5 HT组较NE组相比进一步增加。结论 5 HT加强NE诱发大鼠心肌肥厚和心律失常的作用。

AIM To explore the effects of 5-hydroxytryptamine (5-HT) on cardiac hypertrophy induced by norepinephrine (NE). METHODS Rats were treated with 5-HT 2 mg·kg -1 ,NE 2 mg·kg -1 or NE 2 mg·kg -1 +5-HT 2 mg·kg -1 (ip, twice daily for 15 d) respectively. On 16th day the rats were anesthetized and given iv accumulative dosage of 5-HT to observe the changes in blood pressure (BP) and electrocardiogram. Then the rate of heart weight to body weight (HW/BW) was measured. RESULTS 5-HT(iv, accumulative dosage) markedly increased BP and the number of ventricular tachycardia and fibrillation in groups of NE and 5-HT+NE, and there was no statistical difference between the two groups. The HW/BW increased notably in groups of NE and 5-HT+NE, and the increment of ratio was bigger in group of 5-HT+NE than group of NE 〔(3.5±0.2) vs (3.2±0.1)g·kg -1 , P<0.05〕. CONCLUSION 5-HT enhances the effect of NE inducing cardiac hypertrophy and arrhythmia.