中枢Sigma受体药理学研究进展

Progresses in pharmacological action of cerebral σ receptor

广泛分布于中枢神经系统的Sigma (σ)受体在调节NMDA能、多巴胺能、胆碱能神经系统和神经肽及神经甾体激素功能中发挥重要作用 ,参与学习记忆、条件性恐惧应激反应、精神分裂症等生理病理过程。σ受体药理学的研究将为临床诊断治疗提供新的靶点。

σreceptors are particularly abundant in the CNS. σ receptors have been shown to exhibit such a wide variety of actions as modulating glutaminergic, dopaminergic and cholinergic neurotransmission. They also play an important role in maintaining cell growth and proliferation, learning and memory. Recent evidence suggests the possible involvement of σ receptors in the pathogenesis of schizophrenia. More researches are expected to supply new targets for treatment and diagnosis.